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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC22A1
All Species:
24.24
Human Site:
S59
Identified Species:
53.33
UniProt:
O15245
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15245
NP_003048.1
554
61188
S59
S
P
G
V
A
E
L
S
Q
R
C
G
W
S
P
Chimpanzee
Pan troglodytes
XP_527554
552
60658
S59
S
P
G
V
A
E
L
S
Q
R
C
G
W
S
P
Rhesus Macaque
Macaca mulatta
XP_001098823
554
61424
S59
S
P
G
V
A
E
L
S
Q
R
C
G
W
S
H
Dog
Lupus familis
XP_850971
554
60920
G59
S
P
G
A
A
E
L
G
R
R
C
G
W
S
A
Cat
Felis silvestris
Mouse
Mus musculus
O08966
556
61503
S59
S
P
G
V
A
E
L
S
Q
R
C
G
W
S
P
Rat
Rattus norvegicus
Q63089
556
61523
S59
N
P
G
V
A
E
L
S
Q
R
C
G
W
S
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419622
554
62301
S59
S
P
G
V
V
E
L
S
Q
R
C
G
W
S
L
Frog
Xenopus laevis
Q66J52
552
61646
T58
I
N
G
T
Y
E
E
T
N
F
T
G
P
W
L
Zebra Danio
Brachydanio rerio
NP_998315
562
62704
R59
D
P
G
V
S
E
I
R
E
R
C
G
W
S
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCA2
548
60985
S62
N
G
S
I
Y
E
L
S
P
H
L
W
N
L
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U539
585
65444
V66
A
F
N
I
P
F
V
V
G
N
P
P
H
T
C
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.9
91.1
79.9
N.A.
77.8
78
N.A.
N.A.
63.9
33.3
47.3
N.A.
34.4
N.A.
27.6
N.A.
Protein Similarity:
100
95.8
93.5
86.8
N.A.
88.3
87.9
N.A.
N.A.
77.4
52.3
67.2
N.A.
53.7
N.A.
46.8
N.A.
P-Site Identity:
100
100
93.3
73.3
N.A.
100
86.6
N.A.
N.A.
86.6
20
60
N.A.
20
N.A.
0
N.A.
P-Site Similarity:
100
100
93.3
80
N.A.
100
93.3
N.A.
N.A.
86.6
26.6
80
N.A.
33.3
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
10
55
0
0
0
0
0
0
0
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
73
0
0
0
10
% C
% Asp:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
91
10
0
10
0
0
0
0
0
0
% E
% Phe:
0
10
0
0
0
10
0
0
0
10
0
0
0
0
0
% F
% Gly:
0
10
82
0
0
0
0
10
10
0
0
82
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
10
0
0
10
0
10
% H
% Ile:
10
0
0
19
0
0
10
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
73
0
0
0
10
0
0
10
28
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
19
10
10
0
0
0
0
0
10
10
0
0
10
0
0
% N
% Pro:
0
73
0
0
10
0
0
0
10
0
10
10
10
0
28
% P
% Gln:
0
0
0
0
0
0
0
0
55
0
0
0
0
0
10
% Q
% Arg:
0
0
0
0
0
0
0
10
10
73
0
0
0
0
0
% R
% Ser:
55
0
10
0
10
0
0
64
0
0
0
0
0
73
10
% S
% Thr:
0
0
0
10
0
0
0
10
0
0
10
0
0
10
0
% T
% Val:
0
0
0
64
10
0
10
10
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
10
73
10
0
% W
% Tyr:
0
0
0
0
19
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _